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The optimal duration of clopidogrel has not been established, and duration of use by physicians varies from weeks to months.

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Comment: Although the exact mechanism is unclear, it is highly likely that clopidogrel, like ticlopidine, causes TTP in rare cases.

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There's little reason not to substitute aspirin, a widely available and very cheap drug, for Plavix, a very expensive one, if Plavix is not safe to the stomach, he said.

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The incidences of rash and diarrhoea were statistically significantly higher in the clopidogrel group than the aspirin group.

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